According to Drugs.com, Prilosec or omeprazole belongs to a class of drugs known as proton pump inhibitors. Proton pump inhibitors are drugs used to suppress or block the production of stomach acid. Plavix or clopidogrel is an antipalatelet drug used to prevent blood clots in patients with high risks of stroke and heart attack. Gastrointestinal effects of Plavix include heartburn and gastrointestinal bleeding. Use of Prilosec together with Plavix is discouraged because dangerous drug interaction.
1. Increased Risk for Blood Clots and Heart Attack
The Food and Drug Administration website states that the concurrent use of Plavix and omeprazole reduces the effectiveness of Plavix clot fighting ability. Prilosec blocks the anti-clotting effectiveness of Plavix, which increases the risk of blood clots and heart attack in patients with certain cardiovascular problems. Patients taking Plavix should inform the doctor before taking over-the-counter Prilosec for heartburn prevention.
2. Common Side Effects
According to Drugs.com, patients may experience less harmful side effects while using Prilosec and Plavix. Common effects of Prilosec include headache, dizziness, diarrhea, abdominal pain, constipation and diarrhea. Common effects of Plavix include nausea, heartburn, diarrhea, abdominal pain, cough, headache, fatigue, muscle pain and palpitations
3. Adverse Side Effects
Drugs.com states that use of Prilosec and Plavix may cause life-threatening side effects. Adverse side effects of Prilosec include bone fractures, inflammation of the pancreas, kidney damage, liver damage, damage to blood cells, upper respiratory infections and otitis media. Adverse side effects of Plavix include internal bleeding, hives, influenza like symptoms, liver inflammation and inflammation of the pancreas.