Whole soy germ based nutritional supplement containing Natural S-equol decreases the frequency of modest to acute hot flashes also decreasing muscle and joint pain. This is the first study of this type among postmenopausal American women, according to a peer reviewed information as a poster demonstration at the North American Menopause Society (NAMS) Annual Meeting. This is also the first study to address Natural S-equol safety in a presentation.
Dr. Belinda H. Jenks, PhD, co-writer of the US women’s and safety study also director of Scientific Affairs & Nutrition Education Pharmative LLC, state that the information they have obtained from US women broaden their knowledge and substantiate earlier research in Japanese women concerning the benefit of a supplement which contains the soy-based compound Natural S-equol to handle menopausal symptoms which include the rate of hot flashes and muscle ache. This study along with other studies on Natural S-equol are part of a intense clinical cooperative program of Pharmavite LLC and Otsuka Pharmaceutical Co., Ltd.
S-equol is a compound which is derived when certain bacteria are existing in the digestive tract occurring from a natural metabolism or alternation of daidzein, found in whole soy beans. Not all persons have the ability to produce S-equol after eating soy. The production is dependent on the kinds of bacteria existing in the large intestines and can be influenced by the amounts of soy consumed. Around 50% of Asians and 20 to 30% of North Americans and Europeans, who generally consume less soy than Asians, have the ability for the production of S-equol. Research has shown that Japanese women have easier menopausal symptoms in those that produce S-equol in comparison to those that do not.
S-equol carefully attaches to the receptors for the natural occurring estrogen (female sex hormone) with a strong closeness to the estrogen receptor beta. Upon attaching the receptors, S-equol imitates a few, activities of natural estrogen. Due to the action at the receptors, it has been suggested that S-equol may ease some of the symptoms which are due to decreased estrogen production during menopause.
US women decreased hot flashes with S-equol
A double blind study of 102 American postmenopausal women daily for eight weeks had taken SE5-OH supplement doses of 10, 20, or 40mg of Natural S-equol which decreased the rate of moderate to acute hot flashes and 50mg of soy isoflavone supplement produced the same effect. Isoflavones are known to produce mild effects on the decrease of hot flashes in menopausal women. The researchers had used an isoflavone supplement as a comparison source for the study.
Among the women those in the 10, 20 or 40 mg S-equol group experienced a 50% or more reduction in hot flash frequency than the isoflavone group who had experienced a 16% reduction. All women who had participated in this study had to have had experienced greater than 35 hot flashes a week.
The 10 and 20mg doses were almost the same however the 40mg gave much better results.
Muscle and joint pain reduction of 10 and 20mg S-equol group was greatly reduced compared to that of the isoflavone group.
When combined together the information documents a minimum daily dose of 10mg would give the benefit of both reduction of rate of moderate to severe hot flashes and decrease of muscle and joint pain.
The trail did note some resulting side effects in participants in all groups. These effects occurred in more than 5% of each group which had included bloating, constipation and lining thickening of the uterus.
This study is the first to provide proof that daily dose of SE5-OH supplements which contain 10mg of S-equol taken for one year greatly prevented bone break down in postmenopausal women also the dosage greatly prevented a decline in whole body mineral density.
The findings in this study heighten the possibility that daily 10mg doses of S-equol may add to bone health with negative effects in postmenopausal women that cannot produce S-equol in their bodies.
Research is continuing of SE5-OH containing S-equol being conducted by Sage Saga Nutraceuticals Research Institute of Otsuka Pharmaceutical Co., Ltd. Pharmavite LLC, the makers of Nature Made® vitamins and minerals and a subsidiary of Otsuka, for the management of menopausal symptoms.
Currently there are some top choice natural alternatives for menopause:
Black cohosh (Remifemin) is vastly available and is noted by the North American Menopause Society that it may help for hot flashes, night sweats and vaginal dryness in short term use (about six months). Safety beyond that point currently is not established.
Flax seed (linseed) is thought to have the ability to reduce symptoms of menopause especially hot flashes. Also, some studies have shown it may be able to decrease the risk of breast cancer. It can be purchased as a whole seed, ground up meal and oil seed form. The crush and ground forms are the types our body can digest.
Chinese ginseng used for physical and mental fatigue, anxiety and stress. Since it is root you can take up to 46g a day. Be aware of side effects which include breast pain and insomnia. Due to the fact it is a tonic herb it can be used for a few months at a time.
Chiropractic encourages function and repair communication and coordinating the nervous system by way of subluxation detection and correction. These factors influence the hormonal system.
Estrogen and progesterone are stimulated by the anterior pituitary gland which is controlled by the hypothalamus part of your brain. It receives its information from internal organs through the nervous system which is located in the spine.
The hypothalamus not only regulates the estrogen and progesterone but also gets information from other parts of the brain also, these systems control functions of the body such as sex drive, emotions, body temperatures and sleeping patterns.
Chiropractors distinctively deal with the nervous system and spine. When the spine is under stress, irritates and decreases the function of nerves which send signals to control levels of estrogen and progesterone. Every day stress such as sitting for long time periods can often cause spinal misalignment causing subluxation.
Chiropractors decrease or eliminate the misalignment. Due to the fact the nervous system controls all functions of your body it is essential that you have your spine checked on a regular basis which is about every four to six weeks.
Chiropractic care with regular exercise, hormone free diet (as much as possible) and adequate rest will aide in management and diminish effects of menopause.
Researchers have discovered that just seven weeks of acupuncture can decrease the severity of nighttime hot flashes by 28% in women with menopause. Acupuncture can also aide in overcoming fatigue and insomnia, improve circulation, along with decreasing aches and pains.
Massage therapists offer a range of services for menopausal women that include:
massage especially to the abdomen and lower back
aromatherapy treatment that consists of Clary sage
seaweed wraps/body wraps for sensitive skin
reflexology an alternative to synthetic hormonesSources:
Medical News Today